Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins-Reference-Cited by-同舟云学术

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins

Published:2020-10-13 Issue:43 Volume:142 Page:18522-18531
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Tokunaga Keisuke¹,Sato Mami¹,Kuwata Keiko²,Miura Chizuru¹,Fuchida Hirokazu¹,Matsunaga Naoya¹,Koyanagi Satoru¹,Ohdo Shigehiro¹,Shindo Naoya¹^ORCID,Ojida Akio¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

2. Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c07490

Reference63 articles.

1. Covalent Modifiers: An Orthogonal Approach to Drug Design

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4. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

5. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

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