Covalent Modifiers: An Orthogonal Approach to Drug Design
Author:
Affiliation:
1. Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm8008597
Reference98 articles.
1. Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development
2. A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
3. Elucidating mechanisms of drug-induced toxicity
4. Toxicophores: Investigations in drug safety
5. Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective
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