Cytochrome P450-Catalyzed Degradation of Nicotine: Fundamental Parameters Determining Hydroxylation by Cytochrome P450 2A6 at the 5′-Carbon or theN-Methyl Carbon-Reference-Cited by-同舟云学术

Cytochrome P450-Catalyzed Degradation of Nicotine: Fundamental Parameters Determining Hydroxylation by Cytochrome P450 2A6 at the 5′-Carbon or theN-Methyl Carbon

Published:2012-06-29 Issue:27 Volume:116 Page:7827-7840
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Kwiecień Renata A.¹,Le Questel Jean-Yves¹,Lebreton Jacques¹,Delaforge Marcel²,André François²,Pihan Emilie²,Roussel Anaïs²,Fournial Anaïs¹,Paneth Piotr³,Robins Richard J.¹

Affiliation:

1. Laboratory for the Study of Biosynthesis by Isotopic Spectroscopy, Interdisciplinary Chemistry: Synthesis, Analysis and Modeling (CEISAM), UMR6230, University of Nantes-CNRS, 2 rue de la Houssinière, BP 92208, F-44322 Nantes 3, France

2. Laboratoire Stress Oxydant et Détoxication, CNRS UMR8221, iBiTec-S/SB2SM, CEA Saclay, 91191 Saclay, France

3. Laboratory for Isotope Effects Studies, Faculty of Chemistry, Institute of Applied Radiation Chemistry, University of Technology Lodz, Zeromskiego 116, 90-924 Łodź, Poland

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp304276v

Reference75 articles.

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2. P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

3. Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity

4. Conformational Plasticity and Structure/Function Relationships in Cytochromes P450

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