Mechanistic aspects of reactive metabolite formation in clomethiazole catalyzed biotransformation by cytochrome P450 enzymes-Reference-Cited by-同舟云学术

Mechanistic aspects of reactive metabolite formation in clomethiazole catalyzed biotransformation by cytochrome P450 enzymes

Published:2023 Issue:35 Volume:21 Page:7158-7172
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kamel Emadeldin M.¹^ORCID,Tawfeek Ahmed M.²,El-Bassuony Ashraf A.¹,Lamsabhi Al Mokhtar³⁴^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt

2. Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

3. Departamento de Química, Módulo 13, Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC Cantoblanco, Madrid 28049, Spain

4. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, Madrid 28049, Spain

Abstract

Clomethiazole is likely to contribute to the mechanism-based inactivation of P450 by forming clomethiazole epoxide or hydroxyl adducts, rather than further metabolization to adverse reactive metabolites in its catalyzed biotransformation pathways.

Funder

King Saud University

Ministerio de Ciencia e Innovación

Comunidad de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01014G

Reference55 articles.

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5. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans

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