Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles-Reference-Cited by-同舟云学术

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles

Published:2023-08-03 Issue:37 Volume:145 Page:20403-20411
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Yu Zhongtang¹²³,He Xiaoqiang¹²³,Wang Ruiliu¹²³,Xu Xinxin¹²³,Zhang Zhang¹²³,Ding Ke¹²³,Zhang Zhi-Min¹²³,Tan Yi¹²³^ORCID,Li Zhengqiu¹⁴²³^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development (MOE), Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

2. Guangzhou City Key Laboratory of Precision Chemical Drug Development, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

3. School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

4. MOE Key Laboratory of Tumor Molecular Biology, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

Funder

Science and Technology Planning Project of Guangdong Province

Guangdong Provincial Pearl River Talents Program

Guangzhou Municipal Science and Technology Project

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c05899

Reference31 articles.

1. RAS-targeted therapies: is the undruggable drugged?

2. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

3. Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

4. Drugging the undruggable RAS: Mission Possible?

5. A model for RAS mutation patterns in cancers: finding the sweet spot

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