Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters-Reference-Cited by-同舟云学术

Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters

Published:2023-10-02 Issue:40 Volume:145 Page:22041-22046
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Casamajo Arnau Rué¹^ORCID,Yu Yuqi¹,Schnepel Christian²^ORCID,Morrill Charlotte¹,Barker Rhys¹,Levy Colin W.¹,Finnigan James³,Spelling Victor⁴^ORCID,Westerlund Kristina⁵,Petchey Mark⁶,Sheppard Robert J.⁵,Lewis Richard J.⁷^ORCID,Falcioni Francesco⁸,Hayes Martin A.⁶^ORCID,Turner Nicholas J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom

2. School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Industrial Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center, 11421 Stockholm, Sweden

3. Prozomix Ltd, Building 4, West End Ind. Estate, Haltwhistle NE49 9HA, United Kingdom

4. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Mölndal, 431 50 Gothenburg, Sweden

5. Medicinal Chemistry, Research and Early Development; Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal, 431 50 Gothenburg Sweden

6. Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Mölndal, 431 50 Gothenburg, Sweden

7. Department of Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, 43183 Mölndal, Sweden

8. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, CB21 6GP Cambridge, United Kingdom

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

European Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c07010