Application of Directed Evolution and Machine Learning to Enhance the Diastereoselectivity of Ketoreductase for Dihydrotetrabenazine Synthesis-Reference-Cited by-同舟云学术

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Application of Directed Evolution and Machine Learning to Enhance the Diastereoselectivity of Ketoreductase for Dihydrotetrabenazine Synthesis

Published:2024-06-26 Issue:7 Volume:4 Page:2547-2556
ISSN:2691-3704
Container-title:JACS Au
language:en
Short-container-title:JACS Au

Author:

Huang Chenming¹,Zhang Li¹,Tang Tong¹,Wang Haijiao¹,Jiang Yingqian¹,Ren Hanwen¹,Zhang Yitian¹,Fang Jiali¹,Zhang Wenhe²,Jia Xian³,You Song²,Qin Bin¹^ORCID

Affiliation:

1. Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People’s Republic of China

2. School of Life Sciences and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People’s Republic of China

3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang 110016, People’s Republic of China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacsau.4c00284

Reference52 articles.

1. Biocatalysis

2. Biocatalysis: Enzymatic Synthesis for Industrial Applications

3. Design of an in vitro biocatalytic cascade for the manufacture of islatravir

4. Drug Discovery and Development

5. Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters

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