Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice-Reference-Cited by-同舟云学术

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Published:2013-03-19 Issue:6 Volume:56 Page:2690-2694
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tehler Ulrika¹,Fagerberg Jonas H.¹,Svensson Richard¹,Larhed Mats²,Artursson Per¹,Bergström Christel A. S.¹

Affiliation:

1. Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, P.O. Box 580, SE-751 23 Uppsala, Sweden

2. Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301721e

Reference20 articles.

1. What determines drug solubility in lipid vehicles: Is it predictable?

2. Poorly Soluble Marketed Drugs Display Solvation Limited Solubility

3. Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

4. Molecular Characteristics for Solid-State Limited Solubility

5. A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

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