Evaluation on Characteristics of Anticancer and Antimicrobial Activities with Cipla Loaded ZnO Nanostructural Rods for Human Breast Cancer Cell Line Targeting

Abstract

Abstract A ciprofloxacin-ZnO nanoparticle-based formulation for biocompatible nanodrug delivery has been developed and validated on breast cancer cells. The ciprofloxacin medication was combined with the generated znO nanoparticles utilising a simple chemical process. The structural and morphological study has been revealed using Scanning Electron Microscopy (FESEM) analysis. The crystallinity behaviour of ZnO nanoparticles has been reported previously, which helps to suggest for further biological applications. To enhance the structural study, ciprofloxacin loaded ZnO nanoparticles was revealed to have flower like structure. Their structural analysis was subsequently investigated utilising FESEM after the medication was loaded. From the biological study, ciprofloxacin – ZnO NPs showed excellent cytotoxicity behaviour in MCF-7 cell line which was found from confocal microscopy images using Methylthiazolyl Diphenyl-Tetrazolium Bromide (MTT) assay technique. Antibacterial research also provided support for their other biological functions. A remarkable drug delivery approach for breast cancer therapy may be possibly given by ZnO NPs' suggesting drug loading capacity aids in prolonged release, predominant cancer cell uptake, effective cytotoxicity and better biological profile.