4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity-Reference-Cited by-同舟云学术

4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Published:2014-06-11 Issue:12 Volume:57 Page:5419-5434
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Naik Maruti,Humnabadkar Vaishali,Tantry Subramanyam J.,Panda Manoranjan,Narayan Ashwini,Guptha Supreeth,Panduga Vijender,Manjrekar Praveena,Jena Lalit kumar,Koushik Krishna,Shanbhag Gajanan,Jatheendranath Sandesh,Manjunatha M. R.,Gorai Gopinath,Bathula Chandramohan,Rudrapatna Suresh,Achar Vijayashree,Sharma Sreevalli,Ambady Anisha,Hegde Naina,Mahadevaswamy Jyothi,Kaur Parvinder,Sambandamurthy Vasan K.,Awasthy Disha,Narayan Chandan,Ravishankar Sudha,Madhavapeddi Prashanti,Reddy Jitendar,Prabhakar KR,Saralaya Ramanatha,Chatterji Monalisa,Whiteaker James,McLaughlin Bob,Chiarelli Laurent R.¹,Riccardi Giovanna¹,Pasca Maria Rosalia¹,Binda Claudia¹,Neres João²,Dhar Neeraj²,Signorino-Gelo François²,McKinney John D.²,Ramachandran Vasanthi,Shandil Radha,Tommasi Ruben,Iyer Pravin S.,Narayanan Shridhar,Hosagrahara Vinayak,Kavanagh Stefan³,Dinesh Neela,Ghorpade Sandeep R.

Affiliation:

1. Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 27100 Pavia, Italy

2. École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

3. Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 2NA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5005978

Reference26 articles.

1. The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis