Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

Published:2012-09-05 Issue:150 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Neres João¹²³,Pojer Florence¹²,Molteni Elisabetta¹⁴,Chiarelli Laurent R.¹⁴,Dhar Neeraj¹²,Boy-Röttger Stefanie¹²,Buroni Silvia¹⁴,Fullam Elizabeth¹²,Degiacomi Giulia¹⁴,Lucarelli Anna Paola⁴,Read Randy J.⁵,Zanoni Giuseppe⁶,Edmondson Dale E.⁷,De Rossi Edda¹⁴,Pasca Maria Rosalia¹⁴,McKinney John D.¹²,Dyson Paul J.³,Riccardi Giovanna¹⁴,Mattevi Andrea⁴,Cole Stewart T.¹²,Binda Claudia¹⁴

Affiliation:

1. More Medicines for Tuberculosis (MM4TB) Consortium.

2. Global Health Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

3. Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

4. Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.

5. Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

6. Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.

7. Department of Biochemistry, Emory University, Atlanta, GA 30322, USA.

Abstract

The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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