Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors
Author:
Affiliation:
1. Department of Chemistry and §Department of Biology, Vertex Pharmaceuticals (Europe) Ltd., 88 Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm101499u
Reference32 articles.
1. TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION
2. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
3. Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells
4. Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity
5. Mutation of Tec family kinases alters T helper cell differentiation
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