C‐5 Aryl Substituted Azaspirooxindolinones Derivatives: Synthesis and Biological Evaluation as Potential Inhibitors of Tec Family Kinases-Reference-Cited by-同舟云学术

C‐5 Aryl Substituted Azaspirooxindolinones Derivatives: Synthesis and Biological Evaluation as Potential Inhibitors of Tec Family Kinases

Published:2021-09 Issue:33 Volume:2021 Page:4630-4640
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur. J. Org. Chem.

Author:

Mudasani Gopal¹²,Paidikondala Kalyani¹,Gurská Soňa³,Maddirala Shambabu Joseph²,Džubák Petr³,Das Viswanath³,Gundla Rambabu¹

Affiliation:

1. Department of Chemistry, School of Science GITAM (Deemed to be University) Hyderabad 502102 Telangana India

2. Medicinal Chemistry Laboratory Division AragenLifesciences Pvt. Ltd Survey No: 125(Part) & 126, IDA Mallapur Hyderabad 500 076 India

3. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry Czech Advanced Technology and Research Institute Palacký University Olomouc Hněvotínská 1333/5 77900 Olomouc Czech Republic

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejoc.202100699

Reference41 articles.

1. The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

2. Spirotryprostatin B, a Novel Mammalian Cell Cycle Inhibitor Produced by Aspergillus fumigatus.

4. Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

5. Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach