Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation-Reference-Cited by-同舟云学术

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

Published:2015 Issue:66 Volume:51 Page:13113-13116
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhou Rui¹²³⁴⁵,Wu Qinjie¹²³⁴⁵,Guo Mingrui¹²³⁴⁵,Huang Wei⁶⁷⁸⁹¹⁰,He Xianghong⁶⁷⁸⁹¹⁰,Yang Lei⁶⁷⁸⁹¹⁰,Peng Fu¹¹¹²¹³⁵,He Gu¹²³⁴⁵,Han Bo⁶⁷⁸⁹¹⁰

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University

4. Chengdu 610041

5. China

6. State Key Laboratory Breeding Base of Systematic Research

7. Development and Utilization of Chinese Medicine Resources

8. School of Pharmacy

9. Chengdu University of Traditional Chinese Medicine

10. Chengdu 611137

11. School of Chinese Medicine

12. University of Hong Kong

13. Hong Kong

Abstract

The enantioselective preparation of bioactive chroman-fused spirooxindoles is described. Compound 7e induced apoptosis and cell cycle arrest in MCF-7 cells by interfering with the p53–MDM2 interaction.

Funder

Foundation for the Author of National Excellent Doctoral Dissertation of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC04968G

Reference50 articles.

1. Asymmetric Organocatalytic Domino Reactions

2. Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

3. N-Heterocyclic Carbene Catalyzed Domino Reactions

4. Recent Developments in Asymmetric Organocatalytic Domino Reactions

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