[3+2] Cycloaddition mediated synthesis of spirooxindole pyrrolidine/piperidine fused chromene aldehyde derivatives: DFT studies, antibacterial evaluation and molecular docking investigation as DNA gyrase inhibitors

Abstract

A series of diverse 2′-oxo-6b,7,8,9-tetrahydro-6H-spiro[chromeno[3,4-a]pyrrolizine-11,3′-indoline]-6a(11aH)-carbaldehyde derivatives are synthesized and antibacterial evaluation is done along with computational studies.