The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent-Reference-Cited by-同舟云学术

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

Published:2014-06-24 Issue:1 Volume:58 Page:147-169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sampson Peter B.¹,Liu Yong¹,Forrest Bryan¹,Cumming Graham²,Li Sze-Wan¹,Patel Narendra Kumar¹,Edwards Louise¹,Laufer Radoslaw¹,Feher Miklos¹,Ban Fuqiang¹,Awrey Donald E.¹,Mao Guodong¹,Plotnikova Olga¹,Hodgson Richard¹,Beletskaya Irina¹,Mason Jacqueline M.¹,Luo Xunyi¹,Nadeem Vincent¹,Wei Xin¹,Kiarash Reza¹,Madeira Brian¹,Huang Ping¹,Mak Tak W.¹,Pan Guohua¹,Pauls Henry W.¹

Affiliation:

1. Campbell Family Institute for Breast Cancer Research, University Health Network, TMDT East Tower, MaRS Centre, 101 College Street, Toronto, Ontario MG5 1L7, Canada

2. Celtic Catalysts, 1-03 Nova Centre, Belfield, Dublin 4, Ireland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5005336

Reference49 articles.

1. Polo-like kinases and the orchestration of cell division

2. Polo-like kinases: conservation and divergence in their functions and regulation

3. Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

4. Polo-like kinase 4: the odd one out of the family

5. SAK/PLK4 Is Required for Centriole Duplication and Flagella Development

Cited by 163 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma;Clinical Cancer Research;2024-06-07

2. Development of Benzimidazole‐Substituted Spirocyclopropyl Oxindole Derivatives as Cytotoxic Agents: Tubulin Polymerization Inhibition and Apoptosis Inducing Studies;ChemMedChem;2024-05-03

3. Synthesis and Utilization of 1H-Indazole N-Oxides in the Production of C3-Functionalized 1H-Indazoles;Synthesis;2024-04-30

4. Centrosomes and associated proteins in pathogenesis and treatment of breast cancer;Frontiers in Oncology;2024-03-28

5. K₂CO₃ Promoted Spirocyclopropanation of Thiazole‐Derived Oxadienes via 1,4‐Addition‐Induced Dearomatization Reaction;ChemistrySelect;2024-03-06