1. Manchester Institute of Biotechnology, School of Chemistry, Faculty of Science and Engineering, University of Manchester, Manchester M1 7DN, U.K.
2. School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, U.K.
3. Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, U.K.