Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase

Author:

Shpilberg O,Jackisch C

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference33 articles.

1. Assouline S, Buccheri V, Delmer A, Doelken G, Gaidano G, McIntyre C, Brewster M, Hourcade-Potelleret F, Sayyed P, Badoux X (2012) Subcutaneous rituximab in combination with fludarabine and cyclophosphamide for patients with CLL: initial results of a phase Ib study (SAWYER [BO25341]) show non-inferior pharmacokinetics and comparable safety to that of intravenous rituximab. Blood 120: Abstract 1637.

2. Bookbinder LH, Hofer A, Haller MF, Zepeda ML, Keller GA, Lim JE, Edgington TS, Shepard HM, Patton JS, Frost GI (2006) A recombinant human enzyme for enhanced interstitial transport of therapeutics. J Control Release 114: 230–241.

3. Chan AL, Leung HW, Lu CL, Lin SJ (2009) Cost-effectiveness of trastuzumab as adjuvant therapy for early breast cancer: a systematic review. Ann Pharmacother 43: 296–303.

4. Davies A, Merli F, Mihaljevik B, Siritanaratkul N, Solal-Céligny P, Boehnke A, Berge C, McIntyre C, Barrett M, Macdonald D (2012) Pharmacokinetics (PK), safety and overall response rate (ORR) achieved with subcutaneous (SC) administration of rituximab in combination with chemotherapy were comparable to those achieved with intravenous (IV) administration in patients (pts) with follicular lymphoma (FL) in the first-line setting: stage 1 results of the phase III SABRINA study (BO22334). Blood 120: Abstract 1629.

5. Del Nagro CJ, Mao CP, Brovarney M (2010) Comparison of B cell depletion mediated by intravenous (IV) Rituxan and Rituxan given subcutaneous (SC) in cynomolgus monkeys. Blood 116: Abstract 3980.

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