Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody-Reference-Cited by-同舟云学术

Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody

Published:2018-03-05 Issue:4 Volume:15 Page:1598-1606
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Wecksler Aaron T.¹,Yin Jian²,Lee Tao Paula¹,Kabakoff Bruce²,Sreedhara Alavattam³^ORCID,Deperalta Galahad¹

Affiliation:

1. Protein Analytical Chemistry Department, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Early Stage Pharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

3. Late Stage Pharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b01128

Reference25 articles.

1. Protect from Light: Photodegradation and Protein Biologics

2. Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development

3. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form

4. Characterization of the Degradation Products of a Color-Changed Monoclonal Antibody: Tryptophan-Derived Chromophores

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