Assessing Photostability of mAb Formulations In Situ Using Light-Coupled NMR Spectroscopy-Reference-Cited by-同舟云学术

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Assessing Photostability of mAb Formulations In Situ Using Light-Coupled NMR Spectroscopy

Published:2024-06-07 Issue:24 Volume:96 Page:9935-9943
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Bramham Jack E.¹,Wang Yujing²,Moore Stephanie A.²,Golovanov Alexander P.¹^ORCID

Affiliation:

1. Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester M1 7DN, U.K.

2. Dosage Form Design & Development, BioPharmaceutical Development, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.4c01164

Reference45 articles.

1. Challenges in the development of high protein concentration formulations

2. Chemical and physical instabilities in manufacturing and storage of therapeutic proteins

3. Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects

4. Sensitizer-mediated photooxidation of histidine residues: Evidence for the formation of reactive side-chain peroxides

5. Photosensitizers Form in Histidine Buffer and Mediate the Photodegradation of a Monoclonal Antibody

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