In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration-Reference-Cited by-同舟云学术

In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration

Published:2021-02-25 Issue:4 Volume:18 Page:1711-1719
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Takagi Toshihide¹,Masada Takato¹,Minami Keiko¹^ORCID,Kataoka Makoto¹^ORCID,Izutsu Ken-ichi²,Matsui Kazuki³,Yamashita Shinji¹^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, Setsunan University, 45−1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

2. National Institute of Health Sciences, Kawasaki, Kanagawa 210-9501, Japan.

3. Sawai Pharmaceutical Co. Ltd, Osaka 532-0003, Japan.

Funder

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c01207

Reference30 articles.

1. Evaluation of a Three Compartment In Vitro Gastrointestinal Simulator Dissolution Apparatus to Predict In Vivo Dissolution

2. The Combination of GIS and Biphasic to Better Predict In Vivo Dissolution of BCS Class IIb Drugs, Ketoconazole and Raloxifene

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