More Than a Gut Feeling─A Combination of Physiologically Driven Dissolution and Pharmacokinetic Modeling as a Tool for Understanding Human Gastric Motility

Author:

Romański Michał1ORCID,Staniszewska Marcela2ORCID,Dobosz Justyna2,Myslitska Daria2,Paszkowska Jadwiga2,Kołodziej Bartosz2,Romanova Svitlana2ORCID,Banach Grzegorz2,Garbacz Grzegorz2,Sarcevica Inese3,Huh Yeamin4,Purohit Vivek4,McAllister Mark3,Wong Suet M.3,Danielak Dorota1ORCID

Affiliation:

1. Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland

2. Physiolution Polska, 74 Piłsudskiego St., 50-020 Wrocław, Poland

3. Worldwide Research and Development, Pfizer R&D UK Ltd., Sandwich, CT13 9NJ, U.K.

4. Worldwide Research and Development, Pfizer Inc., Groton, Connecticut 06340, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Reference47 articles.

1. Perspective on model‐informed drug development

2. Review: Role of Model-Informed Drug Development Approaches in the Lifecycle of Drug Development and Regulatory Decision-Making

3. Model‐Informed Drug Development: Current US Regulatory Practice and Future Considerations

4. Center for Drug Evaluation and Research. Focus Area: Model-Informed Product Development. https://www.fda.gov/science-research/focus-areas-regulatory-science-report/focus-area-model-informed-product-development (accessed 2024–04–08).

5. EMA. Reporting of physiologically based pharmacokinetic (PBPK) modelling and simulation - Scientific guideline. European Medicines Agency. https://www.ema.europa.eu/en/reporting-physiologically-based-pharmacokinetic-pbpk-modelling-simulation-scientific-guideline (accessed 2023–07–24).

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