Insights on the Mechanism of Action of INH-C10 as an Antitubercular Prodrug

Author:

Vila-Viçosa Diogo1,Victor Bruno L.1,Ramos Jorge2,Machado Diana2,Viveiros Miguel2,Switala Jacek3,Loewen Peter C.3ORCID,Leitão Ruben14,Martins Filomena1,Machuqueiro Miguel1ORCID

Affiliation:

1. Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal

2. Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal

3. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada

4. Área Departamental de Engenharia Química, Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, R. Conselheiro Emídio Navarro, 1, 1959-007, Lisboa, Portugal

Funder

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference65 articles.

1. World Health Organization. Global Tuberculosis Report 2016.http://www.who.int/tb/publications/global_report/en/(accessed: Feb 28, 2017).

2. World Health Organization. WHO Factsheet on MDR.http://www.who.int/tb/challenges/mdr/mdr_tb_factsheet.pdf(accessed: Feb 28, 2017).

3. Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

4. New developments in the treatment of drug-resistant tuberculosis: clinical utility of bedaquiline and delamanid

5. QSAR Based Design of New Antitubercular Compounds: Improved Isoniazid Derivatives Against Multidrug-Resistant TB

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