Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Author:

Robl Jeffrey A.1,Sun Chong-Qing1,Stevenson Jay1,Ryono Denis E.1,Simpkins Ligaya M.1,Cimarusti Maria P.1,Dejneka Tamara1,Slusarchyk William A.1,Chao Sam1,Stratton Leslie1,Misra Raj N.1,Bednarz Mark S.1,Asaad Magdi M.1,Cheung Hong Son1,Abboa-Offei Benoni E.1,Smith Patricia L.1,Mathers Parker D.1,Fox Maxine1,Schaeffer Thomas R.1,Seymour Andrea A.1,Trippodo Nick C.1

Affiliation:

1. The Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference31 articles.

1. (a) Lawton, G.; Paciorek, P. M.; Waterfall, J. F. The design and biological properties of ACE inhibitors.Advances in Drug Research; Academic Press Limited:  New York,1992; Vol. 23, pp 161−221.

2. Newer ACE Inhibitors

3. Endopeptidase-24.11 and its inhibitors: Potential therapeutic agents for edematous disorders and hypertension

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