Synthesis of 1,3‐oxazepine derivatives via tandem reaction of 5‐benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

Abstract

AbstractA new and efficient method for synthesizing 1,3‐oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5‐benzylidine Meldrum's acid, followed by a 7‐endo‐cyclization reaction with TosMIC (p‐toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.