Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites

Author:

Huang Kuan-Wei12,Chen Jing-Wen123ORCID,Hua Tzu-Yu3,Chu Yu-Yu123,Chiu Tsai-Yuan12,Liu Jung-Yu12,Tu Chun-I12,Hsu Kai-Cheng4567ORCID,Kao Ya-Ting1238,Chu Jhih-Wei1238,Hsiao Yu-Yuan12389ORCID

Affiliation:

1. Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan

2. Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan

3. Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, 30068, Taiwan

4. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan

5. Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan

6. Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan

7. Biomedical Commercialization Center, Taipei Medical University, Taipei 11031, Taiwan

8. Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan

9. Drug Development and Value Creation Research Center, Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Funder

Ministry of Education

Kaohsiung Medical University

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

General Medicine

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