Accommodation of a 1S-(−)-Benzo[c]phenanthrenyl-N6-dA Adduct in the Y-Family Dpo4 DNA Polymerase Active Site: Structural Insights through Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Accommodation of a 1S-(−)-Benzo[c]phenanthrenyl-N6-dA Adduct in the Y-Family Dpo4 DNA Polymerase Active Site: Structural Insights through Molecular Dynamics Simulations

Published:2005-03-01 Issue:3 Volume:18 Page:441-456
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Wang Lihua¹,Wu Min¹,Yan S. Frank¹,Patel Dinshaw J.¹,Geacintov Nicholas E.¹,Broyde Suse¹

Affiliation:

1. Departments of Biololgy and Chemistry, New York University, New York, New York 10003, and Cellular Biochemistry & Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx049786v

Reference88 articles.

1. Chary, P., and Lloyd, R. S. (1995) In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts.Nucleic Acids Res.23, 1398−1405.

2. Chary, P., and Lloyd, R. S. (1996) Impact of the stereochemistry of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide-deoxyadenosine adducts on resistance to digestion by phosphodiesterases I and II and translesion synthesis with HIV-1 reverse transcriptase.Chem. Res. Toxicol.9, 409−417.

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