Conformational Flexibility of the Benzyl-Guanine Adduct in a Bypass Polymerase Active Site Permits Replication: Insights from Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Conformational Flexibility of the Benzyl-Guanine Adduct in a Bypass Polymerase Active Site Permits Replication: Insights from Molecular Dynamics Simulations

Published:2017-08-31 Issue:11 Volume:30 Page:2013-2022
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Wilson Katie A.¹^ORCID,Wetmore Stacey D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta, Canada T1K 3M4

Funder

Canada Foundation for Innovation

Canada Research Chairs

University of Lethbridge

Natural Sciences and Engineering Research Council of Canada

Alberta Innovates - Technology Futures

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.7b00179

Reference74 articles.

1. NMR Solution Structures of Stereoisomeric Covalent Polycyclic Aromatic Carcinogen−DNA Adducts: Principles, Patterns, and Diversity

2. Atomic Resolution Structures of Dna and Dna Modified By Carcinogens

3. An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

4. C8-linked bulky guanosine DNA adducts: experimental and computational insights into adduct conformational preferences and resulting mutagenicity

5. Toxicology of DNA Adducts Formed Upon Human Exposure to Carcinogens

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