Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study-Reference-Cited by-同舟云学术

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Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study

Published:2019-02-20 Issue:12 Volume:123 Page:2609-2622
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Karhu Lasse¹^ORCID,Magarkar Aniket²^ORCID,Bunker Alex²^ORCID,Xhaard Henri¹^ORCID

Affiliation:

1. Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, POB 56, FI-00014 Helsinki, Finland

2. Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, POB 56, FI-00014 Helsinki, Finland

Funder

Suomen Kulttuurirahasto

Terveyden Tutkimuksen Toimikunta

Orionin Tutkimuss??ti?

Finnish Pharmaceutical Society

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.8b10220

Reference78 articles.

1. Orexin/hypocretin receptor signalling cascades

2. Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

3. Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia

4. Hypocretin (orexin) deficiency in human narcolepsy

5. Orexin Receptors: Pharmacology and Therapeutic Opportunities

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1. Orexins in apoptosis: a dual regulatory role;Frontiers in Cellular Neuroscience;2024-04-12

2. Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma;Pharmaceuticals;2023-11-06

3. Interaction between the Human OX2 Orexin Receptor and Suvorexant and Some of Its Analogues: SAPT (DFT) Interaction Energy Decomposition Analysis;The Journal of Physical Chemistry B;2022-09-27

4. Characteristic structural difference between inactive and active states of orexin 2 receptor determined using molecular dynamics simulations;Biophysical Reviews;2021-11-03

5. Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design;Pharmaceuticals;2021-10-19

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