Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia-Reference-Cited by-同舟云学术

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Published:2010-06-21 Issue:14 Volume:53 Page:5320-5332
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cox Christopher D.¹,Breslin Michael J.¹,Whitman David B.¹,Schreier John D.¹,McGaughey Georgia B.²,Bogusky Michael J.¹,Roecker Anthony J.¹,Mercer Swati P.¹,Bednar Rodney A.³,Lemaire Wei³,Bruno Joseph G.³,Reiss Duane R.⁴,Harrell C. Meacham⁴,Murphy Kathy L.⁴,Garson Susan L.⁴,Doran Scott M.⁴,Prueksaritanont Thomayant⁵,Anderson Wayne B.⁵,Tang Cuyue⁵,Roller Shane⁵,Cabalu Tamara D.⁵,Cui Donghui⁵,Hartman George D.¹,Young Steven D.¹,Koblan Ken S.⁴,Winrow Christopher J.⁴,Renger John J.⁴,Coleman Paul J.¹

Affiliation:

1. Departments of Medicinal Chemistry

2. Chemistry Modeling and Informatics

3. In Vitro Sciences

4. Depression and Circadian Disorders

5. Drug Metabolism

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100541c