Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions-Reference-Cited by-同舟云学术

Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions

Published:2019-06-26 Issue:27 Volume:123 Page:5709-5720
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Calero-Rubio Cesar¹,Saluja Atul²,Sahin Erinc²,Roberts Christopher J.¹^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States

2. Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, New Jersey 08901, United States

Funder

Division of Chemistry

National Institute of Biomedical Imaging and Bioengineering

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b03779

Reference65 articles.

1. Opalescence in Monoclonal Antibody Solutions and Its Correlation with Intermolecular Interactions in Dilute and Concentrated Solutions

2. Challenges in the development of high protein concentration formulations

3. Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

4. Relating Protein–Protein Interactions and Aggregation Rates From Low to High Concentrations

5. Aggregation of Therapeutic Proteins

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models;The Journal of Chemical Physics;2024-09-05

2. Antibody association in solution: cluster distributions and mechanisms;mAbs;2024-04-26

3. Electrostatically Mediated Attractive Self-Interactions and Reversible Self-Association of Fc-Fusion Proteins;Molecular Pharmaceutics;2024-02-09

4. Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations;The Journal of Physical Chemistry B;2024-02-05

5. Protein–water–protein interaction: viscosity and gelation;Functionality of Plant Proteins;2024