Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions
Author:
Affiliation:
1. Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States
2. Drug Product Science and Technology, Bristol-Myers Squibb, New Brunswick, New Jersey 08901, United States
Funder
Division of Chemistry
National Institute of Biomedical Imaging and Bioengineering
Bristol-Myers Squibb
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b03779
Reference65 articles.
1. Opalescence in Monoclonal Antibody Solutions and Its Correlation with Intermolecular Interactions in Dilute and Concentrated Solutions
2. Challenges in the development of high protein concentration formulations
3. Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations
4. Relating Protein–Protein Interactions and Aggregation Rates From Low to High Concentrations
5. Aggregation of Therapeutic Proteins
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