Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis-Reference-Cited by-同舟云学术

Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis

Published:2011-02-15 Issue:14 Volume:133 Page:5363-5371
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Edink Ewald¹,Rucktooa Prakash²,Retra Kim¹,Akdemir Atilla¹,Nahar Tariq³,Zuiderveld Obbe¹,van Elk René³,Janssen Elwin⁴,van Nierop Pim³,van Muijlwijk-Koezen Jacqueline¹,Smit August B.³,Sixma Titia K.²,Leurs Rob¹,de Esch Iwan J. P.¹

Affiliation:

1. Leiden/Amsterdam Center of Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, The Netherlands

2. Divison of Biochemistry, Netherlands Cancer Institute, The Netherlands

3. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, VU University Amsterdam, The Netherlands

4. Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja110571r

Reference40 articles.

1. Transforming fragments into candidates: small becomes big in medicinal chemistry

2. Fragment-based lead discovery: a chemical update

3. A decade of fragment-based drug design: strategic advances and lessons learned

4. A ‘Rule of Three’ for fragment-based lead discovery?

5. Library Design for Fragment Based Screening

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