Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity-Reference-Cited by-同舟云学术

Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity

Published:2009-06-24 Issue:14 Volume:52 Page:4126-4141
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bunnelle William H.¹²,Tietje Karin R.¹²,Frost Jennifer M.¹²,Peters Dan¹²,Ji Jianguo¹²,Li Tao¹²,Scanio Marc J. C.¹²,Shi Lei¹²,Anderson David J.¹²,Dyhring Tino¹²,Grønlien Jens H.¹²,Ween Hilde¹²,Thorin-Hagene Kirsten¹²,Meyer Michael D.¹²

Affiliation:

1. Neuroscience Research, Abbott Laboratories, Department R47W, Building AP9A, Abbott Park, Illinois 60064-6117

2. NeuroSearch A/S, 93 Pederstrupvej, DK-2750 Ballerup, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900249k

Reference74 articles.

1. Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

2. Selective alpha7 nicotinic receptor agents for the treatment of neuropsychiatric diseases