Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings-Reference-Cited by-同舟云学术

Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings

Published:2021-10-04 Issue:10 Volume:12 Page:1605-1612
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Nguyen Huy H.¹,Tahirovic Yesim A.¹,Truax Valarie M.¹,Wilson Robert J.¹^ORCID,Jecs Edgars¹^ORCID,Miller Eric J.¹^ORCID,Kim Michelle B.¹,Akins Nicholas S.¹,Xu Lingjie²,Jiang Yi²,Wang Tao³^ORCID,Sum Chi S.³,Cvijic Mary E.³,Schroeder Gretchen M.³,Wilson Lawrence J.¹^ORCID,Liotta Dennis C.¹^ORCID

Affiliation:

1. Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States

2. Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China

3. Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States

Funder

Winship Invest Prostate Cancer Research Pilot Grant

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00449