Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles

Published:2022-02-18 Issue:5 Volume:65 Page:4058-4084
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jecs Edgars¹^ORCID,Tahirovic Yesim A.¹,Wilson Robert J.¹^ORCID,Miller Eric J.¹^ORCID,Kim Michelle¹,Truax Valarie¹,Nguyen Huy H.¹,Akins Nicholas S.¹,Saindane Manohar¹,Wang Tao²^ORCID,Sum Chi S.²,Cvijic Mary E.²,Schroeder Gretchen M.²,Burton Samantha L.³⁴,Derdeyn Cynthia A.³⁴⁵,Xu Lingjie⁶,Jiang Yi⁶,Wilson Lawrence J.¹^ORCID,Liotta Dennis C.¹^ORCID

Affiliation:

1. Department of Chemistry, Emory University, 1515 Dickey Drive NE, Atlanta, Georgia 30322, United States

2. Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States

3. Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States

4. Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States

5. Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, United States

6. Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China

Funder

Winship Cancer Institute of Emory University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01564

Reference83 articles.

1. Modulation of Chemokine Responses: Synergy and Cooperativity

2. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

3. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

4. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

5. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

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