Opiate Aromatic Pharmacophore Structure−Activity Relationships in CTAP Analogues Determined by Topographical Bias, Two-Dimensional NMR, and Biological Activity Assays-Reference-Cited by-同舟云学术

Opiate Aromatic Pharmacophore Structure−Activity Relationships in CTAP Analogues Determined by Topographical Bias, Two-Dimensional NMR, and Biological Activity Assays

Published:2000-01-28 Issue:4 Volume:43 Page:569-580
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonner G. Gregg¹,Davis Peg¹,Stropova Dagmar¹,Edsall Sidney¹,Yamamura Henry I.¹,Porreca Frank¹,Hruby Victor J.¹

Affiliation:

1. Departments of Biochemistry, Chemistry, and Pharmacology, University of Arizona, Tucson, Arizona 85721

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9900218

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2. Design and synthesis of somatostatin analogs with topographical properties that lead to highly potent and specific .mu. opioid receptor antagonists with greatly reduced binding at somatostatin receptors

3. Topographic design of peptide neurotransmitters and hormones on stable backbone templates: relation of conformation and dynamics to bioactivity

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