Brønsted acid catalyzed enantioselective addition of hydrazones to 3-indolylmethanols-Reference-Cited by-同舟云学术

Brønsted acid catalyzed enantioselective addition of hydrazones to 3-indolylmethanols

Published:2022 Issue:16 Volume:9 Page:4466-4471
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Mader Steffen¹,Maji Modhu Sudan¹²^ORCID,Atodiresei Iuliana¹,Rueping Magnus¹³^ORCID

Affiliation:

1. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany

2. Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India

3. King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal 23955-6900, Saudi Arabia

Abstract

A metal-free synthesis of enantiopure β-substituted tryptophan derivatives was developed. A chiral Brønsted acid enabled the addition of donor-substituted hydrazones to 3-indolylmethanols in excellent yields and enantioselectivities.

Funder

King Abdullah University of Science and Technology

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00840H

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