Parallel Synthesis of 1H-Pyrazolo[3,4-d]pyrimidines via Condensation of N-Pyrazolylamides and Nitriles
Author:
Affiliation:
1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
Funder
Pfizer
Publisher
American Chemical Society (ACS)
Subject
General Chemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acscombsci.7b00116
Reference36 articles.
1. Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies
2. Pyrazolopyrimidine Derivatives as Antineoplastic Agents: with a Special Focus on Thyroid Cancer
3. Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent
4. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase
5. Pyrazoloheteroaryls: Novel p38α MAP kinase inhibiting scaffolds with oral activity
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1. Oxidative Annulation of Aldehydes, 5‐Aminopyrazoles, and Nitriles: Synthesis and Applications of Pyrazolo[3,4‐d]Pyrimidines;Advanced Synthesis & Catalysis;2023-01-31
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