Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase-Reference-Cited by-同舟云学术

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

Published:2010-10 Issue:20 Volume:20 Page:6048-6051
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Staben Steven T.,Heffron Timothy P.,Sutherlin Daniel P.,Bhat Seema R.,Castanedo Georgette M.,Chuckowree Irina S.,Dotson Jenna,Folkes Adrian J.,Friedman Lori S.,Lee Leslie,Lesnick John,Lewis Cristina,Murray Jeremy M.,Nonomiya Jim,Olivero Alan G.,Plise Emile,Pang Jodie,Prior Wei Wei,Salphati Laurent,Rouge Lionel,Sampath Deepak,Tsui Vickie,Wan Nan Chi,Wang Shumei,Weismann Christian,Wu Ping,Zhu Bing-Yan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. PIK3CA is implicated as an oncogene in ovarian cancer

2. High Frequency of Mutations of the PIK3CA Gene in Human Cancers

3. Mutations in a signalling pathway

4. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

5. Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development

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