Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent-Reference-Cited by-同舟云学术

Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent

Published:2010-02 Issue:4 Volume:20 Page:1440-1444
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Curran Kevin J.,Verheijen Jeroen C.,Kaplan Joshua,Richard David J.,Toral-Barza Lourdes,Hollander Irwin,Lucas Judy,Ayral-Kaloustian Semiramis,Yu Ker,Zask Arie

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. For a recent review of mTOR inhibitors in oncology see: Verheijen, J.C.; Yu, K.; Zask, A. Ann. Rep. Med. Chem., John E. Macor, editor, 2008, 43, 189.

2. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

3. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

4. mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

5. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade

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