Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity-Reference-Cited by-同舟云学术

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Published:2022-07-10 Issue:1 Volume:37 Page:1957-1973
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Mandour Asmaa A.¹,Nassar Ibrahim F.²^ORCID,Abdel Aal Mohammed T.³,Shahin Mahmoud A. E.³,El-Sayed Wael A.⁴⁵^ORCID,Hegazy Maghawry⁶,Yehia Amr Mohamed⁶,Ismail Ahmed⁶,Hagras Mohamed⁷,Elkaeed Eslam B.⁸,Refaat Hanan M.¹,Ismail Nasser S. M.¹^ORCID

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt

2. Faculty of Specific Education, Ain Shams University (ASU), Cairo, Egypt

3. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

4. Chemistry Department, College of Science, Qassim University, Qassim, Saudi Arabia

5. Photochemistry Department, National Research Centre, Cairo, Egypt

6. Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

7. Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

8. Department of Pharmaceutical Science, College of Pharmacy, Al Maarefa University, Riyadh, Saudi Arabia

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2086866

Reference44 articles.

1. Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold

2. Targeting tumor cells with pyrazolo[3,4-d]pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target-based mechanisms

3. Protein kinases — the major drug targets of the twenty-first century?

4. Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity

5. Decoding molecular mechanism of inhibitor bindings to CDK2 using molecular dynamics simulations and binding free energy calculations

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