Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission-Reference-Cited by-同舟云学术

Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

Published:2000-12-08 Issue:1 Volume:14 Page:62-70
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kassahun Kelem¹,Pearson Paul G.¹,Tang Wei¹,McIntosh Ian¹,Leung Kwan¹,Elmore Charles¹,Dean Dennis¹,Wang Regina¹,Doss George¹,Baillie Thomas A.¹

Affiliation:

1. Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, and Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx000180q

Reference25 articles.

1. Two Cases of Severe Clinical and Histologic Hepatotoxicity Associated with Troglitazone

2. Troglitazone-Induced Hepatic Failure Leading to Liver Transplantation: A Case Report

3. Hepatic Dysfunction Associated with Troglitazone

4. European Patent EP 0 441 605 A2 (1991).

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