Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260-Reference-Cited by-同舟云学术

Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

Published:2020-07-02 Issue:7 Volume:24 Page:1310-1320
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Vetrichelvan Muthalagu¹^ORCID,Rakshit Souvik²,Chandrasekaran Sathishkumar²,Chinnakalai Karthikeyan²,Darne Chetan Padmakar³,Doddalingappa Dyamanna¹,Gopikumar Indasi¹,Gupta Anuradha¹^ORCID,Gupta Arun Kumar¹,Karmakar Ananta¹^ORCID,Lakshminarasimhan Thirumalai²,Leahy David K.⁴^ORCID,Palani Senthil²,Radhakrishnan Vignesh¹,Rampulla Richard³,Savarimuthu Antony²,Subramanian Varadharajan²,Velaparthi Upender³^ORCID,Warrier Jayakumar⁵,Eastgate Martin D.⁴^ORCID,Borzilleri Robert M.³,Mathur Arvind³,Vaidyanathan Rajappa²^ORCID

Affiliation:

1. Department of Discovery Synthesis, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India

2. Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India

3. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, P.O. Box 5400, Princeton, New Jersey 08543-4000, United States

4. Chemical Process Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

5. Medicinal Chemistry, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00232

Reference42 articles.

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3. Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide’s as an inhibitor of TNF-α production

4. Inhibition of Allergic Dermal Inflammation by the Novel Imidazopyridazine Derivative TAK-427 in a Guinea Pig Experimental Model of Eczema

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