Multikilogram-Scale Preparation of AZD4635 via C–H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture-Reference-Cited by-同舟云学术

Multikilogram-Scale Preparation of AZD4635 via C–H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture

Published:2018-12-20 Issue:1 Volume:23 Page:62-68
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Douglas James J.¹,Adams Bradley W. V.¹,Benson Helen¹,Broberg Karl¹,Gillespie Paul M.²,Hoult Oliver¹,Ibraheem Ameer K.³,Janbon Sophie¹^ORCID,Janin Guillaume¹,Parsons Chris D.¹,Sigerson Ralph C.¹,Klauber David J.¹^ORCID

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Process Safety Group, Drug Substance Manufacture, Pharmaceutical Technology & Development, Global Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

3. Production & Integrity Assurance, Intertek, Manchester Technology Centre, Units 12-15, Longwood Road, Manchester M17 1PZ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00342

Reference16 articles.

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3. An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

4. Recent Advances in the Chemistry of 1,2,4-Triazines

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