Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design-Reference-Cited by-同舟云学术

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

Published:2012-01-27 Issue:5 Volume:55 Page:1898-1903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Congreve Miles¹,Andrews Stephen P.¹,Doré Andrew S.¹,Hollenstein Kaspar¹,Hurrell Edward¹,Langmead Christopher J.¹,Mason Jonathan S.¹,Ng Irene W.¹,Tehan Benjamin¹,Zhukov Andrei¹,Weir Malcolm¹,Marshall Fiona H.¹

Affiliation:

1. Heptares Therapeutics Limited, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201376w

Reference17 articles.

1. Langmead, C. J.; Andrews, S.; Congreve, M.; Errey, J.; Hurrell, E.; Marshall, F. H.; Mason, J. S.; Richardson, C.; Robertson, N.; Zhukov, A.; Weir, M.Identification of Novel Adenosine A2AReceptor Antagonists by Virtual Screening.Just accepted.DOI: 10.1021/jm201455y. Published online:January17, 2012

2. Biophysical Mapping of the Adenosine A2A Receptor

3. Adenosine Receptor Modeling: What Does the A2A Crystal Structure Tell Us?

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