Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design

Author:

Gimenez Luis E.1ORCID,Martin Charlotte2,Yu Jing3,Hollanders Charlie2,Hernandez Ciria C.1,Wu Yiran3,Yao Deqiang3,Han Gye Won4,Dahir Naima S.15,Wu Lijie3,Van der Poorten Olivier2,Lamouroux Arthur2,Mannes Morgane2ORCID,Zhao Suwen3ORCID,Tourwé Dirk2,Stevens Raymond C.3,Cone Roger D.156ORCID,Ballet Steven2ORCID

Affiliation:

1. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium

3. iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China

4. Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California 90089, United States

5. Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States

6. Department of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

Life Sciences Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Office of the Vice President for Research

Vrije Universiteit Brussel

ShanghaiTech University

Publisher

American Chemical Society (ACS)

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