Scaling up a C–H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture-Reference-Cited by-同舟云学术

Scaling up a C–H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture

Published:2022-04-08 Issue:5 Volume:26 Page:1378-1388
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Lyons Amanda Jane¹^ORCID,Clarke Adam¹,Fisk Heidi¹,Jackson Bethany¹,Moore Peter R.²^ORCID,Oke Samantha³,Ronson Thomas O.¹^ORCID,Meadows Rebecca E.¹^ORCID

Affiliation:

1. Chemical Development, Pharmaceutical Technology & Development, Global Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Early Chemical Development, Pharmaceutical Sciences, R&D Biopharmaceuticals, AstraZeneca, Macclesfield SK10 2NA, U.K.

3. Process Safety Group, Drug Substance Manufacture, Pharmaceutical Technology and Development, Global Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00432

Reference21 articles.

1. Iridium-Catalyzed Direct Borylation of Five-Membered Heteroarenes by Bis(pinacolato)diboron: Regioselective, Stoichiometric, and Room Temperature Reactions

2. Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten

3. A Robust Kilo-Scale Synthesis of Doravirine

4. Recent advances in catalytic C−H borylation reactions

5. Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

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