Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octane-Reference-Cited by-同舟云学术

Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octane

Published:2021-06-07 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Maddess Matthew L.¹^ORCID,Cleator Ed²^ORCID,Morimoto Mariko¹,Goodyear Adrian²,Dieguez-Vazquez Alejandro²,Gibb Andrew²,Kirtley Andy²,Wang Jie³,Qi Ji⁴^ORCID,Kong Lingzhu³,Alam Mahbub²,Keen Stephen²,Oliver Steven F.²,Wen Xin¹,Lam Yu-Hong⁵^ORCID

Affiliation:

1. Process Research and Development, Merck & Co., Inc., Boston, Massachusetts 02115, United States

2. Process Research and Development, Merck Sharp & Dohme Ltd, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, U.K.

3. Pharmaron Beijing, Co. Ltd., No. 6 TaiHe Road, BDA, Beijing 100176, China

4. Process Research and Development, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States

5. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00098

Reference26 articles.

1. Six-Membered Heterocycles

2. Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules

3. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

4. Escape from Flatland 2: complexity and promiscuity

5. Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors

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