Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors-Reference-Cited by-同舟云学术

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Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors

Published:2010-04 Issue:8 Volume:20 Page:2644-2647
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Zask Arie,Verheijen Jeroen C.,Richard David J.,Kaplan Joshua,Curran Kevin,Toral-Barza Lourdes,Lucas Judy,Hollander Irwin,Yu Ker

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Defining the Role of mTOR in Cancer

2. Targeting the mTOR signaling network in cancer

3. PI3K pathway alterations in cancer: variations on a theme

4. mTOR Inhibitors in Oncology

5. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potentin vivoantitumor activity

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