Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors
Author:
Affiliation:
1. Janssen Research and Development, LLC., 3210 Merryfield Row, San Diego, California 92121, United States
2. Wellspring Biosciences, 3033 Science Park Dr., Ste. 200, San Diego, California 92121, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00242
Reference30 articles.
1. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
2. Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
3. Drugging the undruggable RAS: Mission Possible?
4. Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies
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